Tweaking/lowering player health for a hardcore experience

It is possible to adjust certain things to some degree, but not quite everything.
QuickEdit is a pretty helpful and powerful tool that can do some of the things that you want.

Additionally, you may want to look at the modding thread for more detailed info:

There are also other great resources for HITMAN modding, such as the modding discord, which is generally considered more active than the modding thread:

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