I’ve never had the pleasure of playing, only watching on YouTube, which is highly unfortunate because not only does it look cool but the final target is presented to be killed in exactly the way I like to kill the Fugitive ET.
The only thing that ever got me was where it fits into the timeline, because it seems to run side-by-side with the main story missions from the first game, at least the Marrakesh and Colorado targets do, but that doesn’t seem possible. But I think I’ve worked it out, and I think the S6 takes place the year before the main game.
Novikov and Margolis are hinted to hold regular shows at the museum, so the first target is at the show that took place last year (I’m assuming different times of year each year, as the a few months prior, 47 would have been at the Christmas fashion show for the Holiday Hoarders).
The second one takes place shortly after Ether completes the lab Caruso asked for.
The third one is tricky as it seems to take place at the riot from the main game, but I’m thinking there was another riot the year before when Strandberg’s crimes first came out and he was arrested. We see in the briefing in the main game that Strandberg is in custody and has already been in court, and I’m guessing Zaydan tried a coup at that time but couldn’t put it together in time, and the S6 target was there to help, and the following year they staged Strandberg’s breakout to get another riot going and this time Zaydan was ready.
The fourth doesn’t seem to be impacting the main game timeline in any way, and the presence of Cross’s group could simply mean that they’ve been staying at the hotel for a really long period, or they keep going back.
The fifth one in Colorado was really hard to reconcile, and for a time I had to assume that there was a huge gap in time from the fourth and fifth targets and that this one took place after 47 finished the storyline in H1 and was in the timeline of H2 before going back to the militia camp, and that the fifth target was overseeing Grey’s people preparing to move out of the camp, and we’re just supposed to ignore the presence of the main targets. But, Rose is only mentioned as hanging met the fifth target in the past, and we know Rose was already s registered target, so Diana already knew about him but maybe didn’t know that he was personally at this camp, and realize the greater significance of it until the following year when 47 first has to stop Nabazov’s conspiracy and then two weeks later go back again, looking for the Shadow Client.
Finally, the last target can take place before or after the main game campaign, since 47 had already been to GAMA before to kill Dimitri Federov, then went again at least a year or two later to kill Owen Cage and Klaus Liebleid, and then three weeks later to deal with Soders and Yamasaki. I’m personally leaning toward before. I think 47 finished the entire S6 contract a few months before Grey sends him to Paris.