IMO it’d have to be really well-designed and with luck on IOI’s side.
Most of the generic complications are just “abide by 1/5th of Silent Assassin” which as the old Contract Creation Guide will tell you is just generally a waste of a Complication.
I think the more bespoke ones like what you mentioned have far greater potential, but even then THREE ETs not originally designed around this have to line up well with a complication (it doesn’t help that No Agility, No Stairs, etc are really easy instafail Complications to mess up) in a manner that is interesting.
For example, I think The Ascensionist with a condition like “if you spend longer than 1 minute on a different floor than the target, you fail the mission, this complication is removed once the target is dead” would be creative and potentially fun… BUT you can’t adapt that to Arcade because that same Complication has to accommodate 2 other Targets