I posted an update in the tech support thread HITMAN 3 - Technical Support - #562 by MrBlarg
It’s definitely not a file thing, I ran Process Monitor to try to find anything like that and there was nothing out of the ordinary in the file system, registry, or network requests. Tweaking various graphics settings in both the driver control panel and in-game let it load and play. However, today the same settings are still crashing a few seconds to a few minutes of gameplay.